Off Label Medications

If you looked into daily lists of biggest NASDAQ loosers provided by platforms like Marketwatch dot com or even yahoo finance you will see ever day mostly pharmaceutical companies that succumbed after a year or two or three of great expectations. Little pharmas with weird names created usually with one purpose only, around one patent, for developing one drug with an even weirder name or one method of therapy or both, with known or unknown promising CEOs that gather capital that ranges into the hundreds of millions (each), that is spent mostly for the creation of facilities, offices and labs. And then after one year or two, the news come. The clinical trial phase "did not show signs of intolerable side effects", "one out of three patients went into remission" etc. and then those companies become yellow bricks in the road paved with good intentions.

I was hopping for a nicer name for the vast category of existing medicines that are potential candidates for treating different diseases that those intended. This article instead has a longer, even harder to conceptualize name. Would cross disease medications sound better for you?

I remember long time ago when internet was much younger and thinner and new data was not already superseding older one, in so many directions, i ran into an article that was stating that antidepressant drugs were discovered by chance, by giving antihistamines to patients before surgery and noticing the sedation effect. When i did the search for that article today, i found that antidepressants and other psycho drugs were discovered by chance by administering anti TBC drugs. Whatever.

It is said that so called first generation of anti-histamines indeed had sedating effects, but starting with cetirizine (Zyrtec), loratadine (Claritin), the sedation effect was supposedly dismissed, which i think is not true, because in both me and Angela Zyrtec has a strong sedation effect that lasts for days. At least until like in the case of antidepressants "your body gets used to".

Lately i was concerned with T gondii (toxoplasmosis) parasite. When talking about this infection agent everybody agrees with to several things. Most overlooked, endemic, "vast majority of cases are subclinical", treatment was abandoned decades ago mostly because is almost asymptomatic in most infected but also because of side effects (toxicity) of "classic" or recommended treatment available then and still now.

Coming from our pets, cats and dogs which are actually domesticated prey animals, that are adapted to live with it as symbiont, infecting the older and immune compromised prey during the so called "marking of the territory", inducing behavioral modification of prey, making it happier and much easier to catch, but also, by example, from beef, where it may be destroyed by a proper cooking.

Why and how the most overlooked parasite modifies the behavior of the infected. By releasing dopamine, the reward chemical, one of the most crucial neurotransmitters that some of the anti-psycho medication go for. (Who would go searching for medical help during the initial phase and also the medium term telling the doctor: Doctor, this morning i felt too good for no reason just because my dog leaked my face!).

To cut it short. Some miners of the vast landfill of existing, some forgotten medicines, identified a number of "compounds" that are good candidates for non-toxic treatment of T gondii (not indigo, bad google). Wondering how many others are still out there. But is it a coincidence the fact  that some are anti-depressant and some anti-histamine?

Could it be that T gondii, the insidious, feel (extraordinarily) good parasite, may be responsible for a much greater array of diseases, some of them mental, and those compounds used for their original, intended, known purposes actually kill or suppress the "subclinical" parasite which is the root cause of those most chronic diseases?

February 22

Boris Johnson sanctions oligarch Gennady Timchenko. Cause Joe Biden could not sanction oli_garch Oleg Deripaska.

Caught in a vise-grip between west and east, all controlled by the same entity, possible of alien origin (i don't believe humans can do this to other humans), with Russians not minding being the bad guys and westerners not minding thinking being the good the whole world has no other choice but sit and watch and hold breath.

February 21

10:45 Today, stock market, federal agencies, some companies (Not Eaton where Angela works today overtime) are closed because of George Washington's birthday.

11:43 Got awakened (can't write "woke up" anymore, that word has been confiscated) at 9:30 by a very pungent smell, reminding roasting hot peepers. (Over the night electricity was cut briefly, stopping one of the filters). Went in the back and stepped on numerous holes, cracks and bulges in the ground, then got away. As i came from walking, a super hungry kitten (with a collar) looking like a panda with white spots under the eyes (one night i saw a Dalmatian looking like a panda in Lincoln City at the Grocery Outlet), was following me on the alley. Didn't want to deal with it so i turned around, the cat was still following. Turned around one more time, the cat saw somebody else and went to him.

As i finished the last match, a girl ran around the building, passing my windows, yelling like crazy. "Oh my God! Oh my God" (the doubling). BTW do you know what kinda god George Washington became? A Shinto god! A Shinto god now painted on the highest point inside the Capitol dome. That's why i call him. White Shinto.

And this is why i came to believe that most of the time, most people don't really know what they're doing.

3:25 Forgotten countries, unknown (to most of us) history. Ruthenians, Rus, Kyiv, Galicia. Western Slavs (or Russians) are those descendants of vikings who never came under Golden Horde rule.

I had no idea that legendary Moldovan king Stephen the Great who ruled Moldova for almost 50 years and fought and won numerous battles against Ottoman Turks contributed to the history of Ukraine (whatever that is today).

4:24 Again the linguistic argument. In this map Kraków is shown not being part of Poland. There is a city in Austria called Graz. Croatia. Bel_Grade. U-kraine. Debrecen in eastern Hungary. All these suggesting a Slavic continuum against the idea of separate Western and Southern Slavs. Interrupted by what? Maybe by Romans, not by Dacians, who where there thousands of years BC. Then Romans ceded Pannonia (most of today's Hungary) to Attila, for the sparing of Rome.

11:02 Was that effective against spying? If it happened (i am not convinced by the scarce pictures i've seen) they probably sacrificed the poor and clueless like they do in today's Japan, to manufacture cars to continue to indebt US. 24,000 that were left outside would have sufficed to report back to Japan everything that was happening in the US.

11:53 Ok i lost last entry, will try to write it again. Just found an fb post since 2013 where for the first time i hypothesized the possibility of actors acting as politicians. Next list on blog is since December 2014 and has many mistakes. But i think there was another list in 2013 on g+. In 2016 i got a pretty good list, and i started the blog with matches in fall 2018, with many mistakes though, and a brief 20% market crash first occurred. But after a series of maneuvers putting me in a very bad light, market recovered in January 2019.

Today i got really mad when i saw the synchronization of what i wrote about the godhood of George Washington and Putin's two decrees. Wondering if they weren't pushing for it. Yesterday in the parking lot at Chinook i almost got into a fight with a couple of guys, one of them cursed of Christ, which made me remember today of George Washington apotheosis while the other, who wasn't speaking English, came out of a car, shirtless.

Peaceful Ukraine separation from the Soviet Union occurred more than 30 years ago. People living in between 2 worlds, with those in western Ukraine having less income than those in the east. 2014. Eromaidan. Unrest starting in the east.

Then the circus with Yanukovich and his golden toilets. I remember i wrote and spoke again before 2014 to many people about the huge amounts of gold taken by Romans from Dacia, about 200 tons per year for 162 years, gold that vanished on imported goods (tens of thousands of tons of gold).

Was it then when they started to use dog poop? I remembered i was gathering pounds of poop from around the building in Lake Oswego and from here, and nowadays they are burning it in the ground.

The accident on August 21 last year. My computer breaking down a few days ago.

And now after a month of market being low, On George Washington birthday Putin remembers of the Russians in eastern Ukraine.

February 20

1:28 My first match done entirely on the new setup (Chromebook with my old keyboard, mouse and monitor). Pixlr for cropping. Please be patient, i'm on a learning curve. Again.

2:40 It's all coming together now (it started to make sense). How come i haven't seen this before? I'm too busy i guess.

2:46/12:46 Da bine da modela mamzela mimoza aia din planul secund cine-i?

7:13 Got awakened by the pungent smell. Went outside and found numerous cracks and bulges in the ground, some under door and walls. Being sleepy and groggy, could not find them the first time. Every time i came inside and closed the door, as the direction of the flow at the surface shifted, more smoke was coming, after a brief pause.

12:41 Took half Zyrtec and slept till now.

repetitio est mater studiorum. They are taking turns at saying this for weeks now on Ukraine.

11:30 Why FCC will let her be?

Will perfect our chemistry. Today, about saltpeter.

The name Peter is the root of the word. Closest to alchemists' philosopher stone. Once used to preserve meat, was rumored to cut sexual urges. Though it didn't exist in Japan when first "edition" of Basenshukai was released (1976) with the purpose to bring in more disciples, it is found in many "fire tools" recipes in the book.

I would not be surprised if Dominicans (the influential catholic sect) would believe it has "divine" properties pretty much like the "hounds of the Lord", oftenly portrayed as Dalmatians with a torch in their mouths. After all, Dominican Inquisition burnt their "heretics" at the stake. ( Could it be the Olympic torch relay is inspired by the hounds running with a torch in their mouth?).

No i wouldn't have bothered to write this at this hour of the night, after driving 80 miles and feeling ready to sleep if it wasn't about me or my life in the last decades. It is about this morning, when the place filled again with an irritating smell that believe it or not, comes from the ground. "It will set the Earth on fire" says St.Dominic's mother dream. And they literally believe that. In order to achieve this, they however need some material things. Among those, saltpeter.

A nitrate of potassium or other metals like calcium, etc., it is an unstable mineral that can be used as fertilizer or as main ingredient in old type (black) gunpowder. The most interesting property of saltpeter is it burns by itself, no oxygen needed. Actually, not by itself, it provides oxygen for other things to burn. Because it has oxygen in its unstable molecule. And yes, they did it again, to complete the cycle. Got to go outside to step on cracks, mounds and holes in the ground, to seal them for at least a few hours. When the smoke subsides, the moles come back, crack the ground again to air their galleries and they can start over.

Why would they do this? For religious reasons of course. To make someone act weird, under this precise type of influence described in the prophecy (St.Dominic mother's dream) so it may contribute to starting of the phenomena described in the last Book of the Bible and thus pave the way for the second coming of Christ.

Think about. If Dominicans believe the hounds (Dalmatians) are holy, that means everything in them is holy, including excrement. Which excrement may be mixed with saltpeter, another magic substance, an inhibitor maybe, set on fire and stuck in the ground (moles galleries, other magic animals that may inspire the freemasons), just like in the prophecy. When burnt, excrement may release aerosols that contain unburnt material that may still contain bacteria and protozoa or whatever lives in that dog's intestines. Small amounts that may travel from underground in somebody's house or apartment and infect everybody inside. Infections with T Gondii may have also very weird effects on people, because the parasite releases dopamine (the reward chemical) and interferes with a person's cognitive cycle, feeding back their belief (of those who do that) that dogs are magic.

February 19

2:02 This is my first post with the new setup. I bought on Amazon a hub that plugs into one of the USB C ports in my Samsung Chromebook 4 and offers 3 USB and one HDMI port. All i had to do is reboot the computer, hook the mouse, keyboard and monitor to the hub and it worked without any other fuss. I am a bit disappointed though because i payed 19 dollars for the hub itself at Amazon and 19 dollars for the HDMI cable at Best Buy across the street (i though i had one, i was to anxious to buy one online and wait till tomorrow to see if it works). I could probably cut the price in half but have to make two returns and it's not worth the trouble. Better view, no more artifacts on screen due to poor old VGA connector, but still have to figure a number of things. Yes you can do it with any laptop that has an USB C port (and of course HDMI, when you don't need any adapter), and probably even with a phone. (Great idea, should try see if can use my phone as a desktop computer, cause it has way more procession power than this chromebook).

2:19 Earlier. I woke up after about 5 hours of sleep because of the pungent smell. My battery connector main screw got stripped last night, i put another one, but the voltage now varies between 12.3 and 14.7 and i measured and this is what's coming from alternator. Could it be the alternator detects low current and stops charging. The truth is i couldn't figure it out and still don't believe in the so called smart charging. When i left for Best Buy i noticed this bulge by the curb next to alley. What they do, is they let the moles do their job and then pierce the soil with some tool and insert something burning in the ground. The mole leaves, temporarily, and the smoke comes out for hours. And nobody knows where from. Smoke composition changes from one day to another, today, last few days brought much irritation, but also have the animal dung component.

4:23 Just figured why i have problems with the battery. Last time i worked at i got frustrated by the noise and acting in the parking lot, and involuntarily (without thinking) hammered the negative terminal. These batteries are supposedly sealed, but i think they do leak at least some vapors of acid and coat the terminal and connector with a fine invisible layer of oxide that after a while break or change the parameters of contact. Alternator will charge, but up to a limit when will stop charging probably due to detecting low current and all electrical systems on the car will work intermittently between 12.5 volts and 14.5, with most dramatic effect on fuel pump, also with some flickering at that critical point. By hammering also by overthinking it i made the leak and the oxide apparent on screws and contacts. I looked at the battery, it looks original, which means 5 years, i am rushing to buy a new one, most likely a generic one. But in the mean time i asked google a question i always wanted to. Why can't use lithium batteries instead of lead on regular (non electric) cars.

Buddha wiser. Last night i was staring at the empty beer can on the dashboard listening to the sound of ocean interrupted only by the many decibels of each vehicle that started and idled profoundly, for minutes, and suddenly had a moment of enlightenment.

9:29 Where are the times when media in the US also played a tiny bit of educational role? Nowadays it seem they rush to pave the way to hell so others could follow. This isn't cold war anymore, it's as hot as it can be, if we judge Ukraine being on the side of the west. This is a real war that started in 2014, where 14k people died already. Not talking about the Yugoslav Wars with Croatians being the good guys and Serbians the bad which happened just because Croatia and parts of Serbia were in the ex Australo-Hungarian Empire (Yugoslavia was multinational, but the Empire wasn't).

11:00 Yeah but how do we know that was real?

11:48 Virginia Giuffre reacts.