A Theory on Alcoholism

The presence of Alcohol Dehydrogenase (ADH) at high levels in the human body triggered by the consumption of alcoholic beverages insures, as a side effect, protection against many types of alcohols including methanol and glycols because it helps metabolizing all those alcohols.

This is the reason ethanol is often used in emergencies as antidote for methanol or glycol accidental ingestions.

Heavy drinkers exhibit a continuous production of high level of dehydrogenase (definition framed here) for years or decades, production triggered in human body only by the consumption of ethanol.

Ethanol is as toxic to humans as methanol but by raising the production of dehydrogenase, the human body can metabolize it.

In the same time ingestion of alcohols other than ethanol generally does not trigger production by the human body of enough of the protecting ADH, thus their very toxic effect.

Both situations are due to genetic factors accumulated by human and other species throughout evolution.

Throughout the whole period of heavy drinking the human body does not need its immune system for fighting against methanol producing bacteria that live in the gut because the methanol produced by those is also metabolized by the ADH of which production is triggered by the ethanol from drinking (and maybe permanently reallocates those resources for producing dehydrogenase for metabolizing both ethanol and methanol and other alcohols produced by the bacteria in the gut or coming from a polluted environment).

It is possible that the immune system by not being used to fight that type of bacteria for so long looses the capacity of fighting it.

That's why they probably can not stop, because of the terrible hangovers given among other things by the methanol produced by those bacteria without the presence of ADH "normally" triggered by drinking alcoholic beverages, bacteria that their immune system abandoned fighting or forgot recognizing.

Maybe the solution could be as simple as vaccination against those so the immune system start recognizing them again.

ADH is always present in healthy individuals in amounts that insure protection against the amounts of all types of alcohols normally present in food. Although only ethanol raises ADH production, the other alcohols present in food or generated by other alcohols production microorganism are always reasonably proportional. Probably ethanol is most common and that's why the human body uses it as trigger in raising ADH production.

By overstimulating the production of ADH with heavy alcohol consumption it is also possible that the production mechanism to be depleted by overuse and/(or more likely) the triggering amount necessary for starting production to become permantely raised so the normal amounts present in food or generated by ethanol or other alcohols producing microorganism living in the gut do not trigger its production before (relatively low) toxic levels are being built, giving hangovers. In this case due to lack of further knowledge, all i can say is it can be imagined a lifelong treatment that may include ADH or other medication that can stimulate the production of it at normal levels.

Oregon Board of Medical Licensing

The big secret is they asked me 25 bucks for each passport size picture and said they otherwise might be blurred as copied by copy machine. Needles to say i gave up. Why is this "classified"?

https://techmedweb.omb.state.or.us/Clients/ORMB/Public/VerificationRequest.aspx

From: George Ion <george.ion.email@gmail.com>
Date: Tue, Jan 22, 2013 at 12:50 PM
Subject: Fwd: dr.Hannes Sigurtsson
To: Randy Day <randy.day@state.or.us>

And most important, if you have a photo of dr.Sigurtsson on file and in general photos of all the doctors listed bellow.

---------- Forwarded message ----------
From: George Ion <george.ion.email@gmail.com>
Date: Tue, Jan 22, 2013 at 12:37 PM
Subject: Fwd: dr.Hannes Sigurtson
To: Randy Day <randy.day@state.or.us>


I apologize, for the last two i mistook names

Rana, Hiren Thakorbhai MD, MD14344Rana, Vandana Hiren MD MD15791

In addition, there's one moreDouglas, Daniel Ray MD MD18403

Here'e the list updated
Bertani    Emily Danielle MD MD152933   
Bindal    Vandana Niraj MD MD23239   
Boboia    Dorina S MD MD14590   
Collier    Jeanine Shannon-Allison MD MD21368   
Douglas, Daniel Ray MD MD18403       
Erickson    Kenneth Reed MD MD13119   
Eusterman    Joseph Huntimer MD MD06417   
Gilligan    John French MD MD20074   
Parent    Joseph Adrien Jr. MD MD08183   
Patil    Ravindra Ramdas MD MD21026   
Piepgrass    Sterling Robin MD MD12092   
Rana    Hiren Thakorbhai MD    MD14344
Rana    Vandana Hiren MD MD15791   

---------- Forwarded message ----------
From: George Ion <george.ion.email@gmail.com>
Date: Tue, Jan 22, 2013 at 12:11 PM
Subject: Re: dr.Hannes Sigurtson
To: Randy Day <randy.day@state.or.us>


Don't know if you noticed, on the attached document he printed his name with a t not d. Please send me any printed document related to him that you can send me for free or for a fee. I reattached the "court order" here. This would not be the first case of mistaken or stolen ID or doctors practicing without license or under fake ID in the State of Oregon. I remember of dr.Patil. By the way, the dr. who treated my wife after her surgery in 2004 at Providence was also named Patil.

Please send me the same printed documents, copies of license or any document i am entitled to ask for free or for a free for the following doctors.

Patil, Ravindra Ramdas MD MD21026
Boboia, Dorina S MD MD14590Gilligan, John French MD MD20074
Bertani, Emily Danielle MD MD152933Piepgrass, Sterling Robin MD MD12092
Parent, Joseph Adrien Jr. MD MD08183Erickson, Kenneth Reed MD MD13119
Eusterman, Joseph Huntimer MD MD06417Bindal, Vandana Niraj MD MD23239
Collier, Jeanine Shannon-Allison MD MD21368
Hiren, Vandana, Doctor's Express, Boones Ferry, Lake Oswego,
Hiren, Rana, ex-Woodland Park Hospital

The last two i cannot find right now in your database, although i could yesterday.

Gheorghe Ion
47 Eagle Crest dr#10
Lake Oswego, OR, 97035

On Tue, Jan 22, 2013 at 8:17 AM, Randy Day <randy.day@state.or.us> wrote:

censored

Randy H. Day
Complaint Resource Officer
Oregon Medical Board
1500 SW First Ave. Suite 620
Portland, OR 97201

Phone - 971-673-2702
FAX - 971-673-2669

Data Classification Level 2 - Limited

randy.day@state.or.us
www.oregon.gov/omb

 

This e-mail is intended for the named recipient only and may not be read, copied, discussed, or distributed by anyone except the named recipient or the agent or employee of the named recipient action upon the named recipient’s directions. The named recipient is responsible for the confidentiality of the message. Notify the sender should any part of the following document(s) fail to transmit correctly. Please destroy incorrectly transmitted documents immediately.

OUR MISSION: To protect the health, safety, and wellbeing of Oregonians by regulating the practice of medicine in a manner that promotes access to quality care.

 

Medical Records, 2002-2003

Date descărcate de la firma de asigurări CIGNA. Clic pentru a mări imaginile. Dacă eram aşa bolnav după cât de rău mă simţeam crăpam de mult. Bani cheltuiţi aiurea care acum sunt pe carduri (perosnal, 1500 pe an şi 10-15% din Total Paid). Prima pagină din 2002 lipseşte.

South West Washington Medical Center, Early 1996

Columbia River Mental Early 1996

050396 Stay of Proceedings

Never knew i had to go to a trial after i was released from jail then from hospital. I was on some sort of medication then i received a letter from the court, with a date, 05-03-1996. Just the day before the court, i found a lawyer, i gave him all my money, 800 dollars, and he seemed to be very concerned about the whole thing, especially of how the Police behaved.

I already had a court appointed attorney but i did not trust her, because she said something about the possibility of the DA to dismiss the case because of my exposure to methyl chloroform at the last job. But when i asked her what the word dismissed means, she said "nevermind". I went home looked into the dictionary, found about that word but she never spoke about it again.

So i found a lawyer and went to court. Right after i came home from the meeting with the lawyer i found on my answering machine (i have a copy of that recording somewhere, i should attache it here) a message from the court appointed attorney saying that the DA is giving me a 1 year stay of prosecution deal, which turned into 2 years the next day. I remember my paid attorney was all perspiring, looked very scared and kept trying to tell me something about the judge never signing the deal, but my wife kept telling me we should take it because we could take our money back from the attorney if there was no trial. So i did and to this day i don't know if the deal was real. All i know is there is no more record of this case at Vancouver District Court or at the Vancouver Police. By the way, the name of the judge is Fred Stocker, i think he is retired.

Providence Scholls

On December 29 2011 i spoke on the phone with Julian Mart, in Seattle. At the time, i thought he fixed his immigration status, but recently i found out he is on a Pulitzer type of visa.

That day i was feeling ill, some trouble breathing, some anxiety attack. He mentioned on the phone he is on another line with "the doctor" and put a heavy accent on that word. I attributed that to his foster care business at his home where he takes care of elderly people.

Later in the evening the symptoms got worse and i decided to go to Providence Scholls. I went and checked in and went to buy some potassium gluconate supplements at the nearby Walgreen's. I think i had in and out atrial fibrillation due to lack of potassium. I noticed there was a black limo in the parking lot and a guy in the waiting room dressed in some sort of unusual, shining leather jacket that seemed young, restless and full of life and not the sick type you usually find in those places throwing at me some sort of arrogant looks and smiles.

When i opened the bottle with the potassium gluconate i just bought, a woman came and called me. She took me to an area where an assistant took my vitals signs. I noticed she was not looking at me while talking, just at the blood pressure and oxygen level monitors, and she asked me again if i really wanted to check in. In a way she seemed familiar to me. Very young, darker skin with some sort of heavy make-up. Later i thought she was looking a lot like Niki Minaj.

So i went in, undressed, put on a gown and the doctor showed up. She introduced herself as dr.Bertani, Emilly. She seemed very young, maybe too young to be a doctor, like in her late 20s. She was kinda hardly trying not to laugh, smiling all the time. She went straight to the computer, asked the usual questions and put the data in. I asked her if she knew dr.Weeks, the doctor i last saw in that clinic, a year before. She said she was there for a very short time, she doesn't know all the doctors. (Please click again on the Providence Scholls link above. You will see the doctors that are working right now in that clinic. Do you think if she was a new doctor in there she wouldn't know them all?).

Among other things that happened in there, one thing caught my attention, although i was feeling really sick and distracted by my symptoms. When she used her stethoscope, she was barely touching me with it, not talking about holding it and listening to anything. My wife is a medical assistant, we have several stethoscopes at home and i learned to used them, including manually checking blood pressure and listening and comparing heart's sounds with those found on several sites on internet. In fact, i remember i told her that i have stethoscopes at home but i don't like to listen to my own heart because i freak out or something like that and she laughed nervously.

Then in the end i used the word breath referring to me breathing hardly and hyperventilating and i think she intentionally mistook the word for breasts and took a sort of embarrassed pose. However, in the end she told me compassionately that i should take care of what she refereed to as "chronic problems". Probably with references to my alleged psychiatric problems in the past.

I went home. About an hour later, i realized she might not have a doctor after all. In fact, she looked a lot like the celebrity known as Lady Gaga.

When i realized that, i decided to go to the ER at Providence St.Vincent hospital. I didn't know at the time what was happening to me and i though maybe it was better so. But driving i thought i was getting better and i was undecided. When at the last stop sign before the hospital, still undecided, some guy driving behind me flashed me with his high beam and i don't know why, that was the final push towards the decision not to go. So i turned back home.

For the last few days i head an ongoing conversation with the Oregon Board of Medicine Licensing. I am intrigued by the fact that they do not have doctors' photographs on their Verification of Licensure page. In Oregon, there have been at least one notorious case of a doctor working without license, dr.Patil. As a coincidence, my wife's ex-oncologist name is Patil.

A few days after i went to Providence Scholls and took a picture at the board at the entrance with the list of doctors. No dr. Bertani in there. I think there was no dr.Bertani working for Providence Scholls, ever.

dr.Sigurtson

In September 2004 my wife had cancer surgery. I was in the same hospital at Providence St.Vincent in Barnes Rd. in Portland, Oregon, in the psychiatric ward due to a psychosis. In fact, i was at the 4th floor while she had surgery at the fifth. She came to see me the second day after surgery, while i was laying in bed thinking i was on a different planet. Could this be related to my downstairs neighbour, a person to whom we both refereed to as "the witch", a 300+ pounds woman with a black cat, stars and moons door mat, and a bumper sticker on her car saying "my other car is a broom", who sometimes was laughing on a really high tone, alone in the house? At 6810, SW Hall Blvd, Beaverton, OR, 97035. Later she moved to a different apartment in the same complex, i think i have a picture of the "things" she kept in front of the door. Here it is...

At Sussex Village Apts, Beaverton, OR, 2007/07/23 18:25:27, click to enlarge

At Providence i was in care of dr.Sigurtson. That's all i remember, his last name. In fact he obtained from Washington county some sort of court order to keep me in there because i wanted to get out.

I remember he enumerated some antidepressants and asked me what i wanted. I chose Remeron (Mirtazapin) because it sounded right to me at that time. I've been on Remeron until early 2007. It took me one full year to fight with the withdrawal symptoms. From what i've heard, i am the first person to ever get off of Remeron. But i believe i got the bradycardia because giving it up. (Remeron as a side effect is a cardiotonic and raises your heart rhythm and after a while your body gets used to and your heart rythm gets back to normal. When you get off it, i suppose it goes down. My pulse now is in the low 50s and even in the upper 40s when i lay down.)

But the strangest thing is a few days into my hospital stay (in fact just after signing the document below) dr.Sigurtson dissapeared. He was replaced by a different doctor, dr.Guistwhite. But by that time, i already gave up, i made peace with myself and everybody. Could it have been the phone calls i made from the hospital to different lawyers from yellow pages trying to describe to them my situation and ask for help? The nurses told me he had an accident. Years later i tried and called the hospital asking them about dr.Sigurtson and they told me he moved into a different country.

Nowadays i am reviewing a number of faces i knew and resemble other persons,  mostly celebrities. Dr. Sigurtson's face look a lot like ...Sigurjón Sighvatsson, the Iceland born actor. Can anybody tell me what the hell is going on?

Sigurjón Sighvatsson

Can get most of the resolution with middle click

I had this document for 8 years. I always hesitated to show it so someone. Why? Because the handwritten parts especially the small letters look exactly like my handwriting, with a few differences though.

How Chest Pain Works

There are more and more numerous and sometimes irreconcilable theories about why chest pain occurs as a symptom of a heart attack. The funniest i heard of so far (actually i heard it in a radio show) is the one that says that they are due to a genetic anomaly. That is some people have some sort of shortcuts in the nervous system, presumbably at the spine level that transmit signals of a heart attack perceived by the brain as chest pain.

That's when i knew that there is yet another crisis in the theory of medicine. 

None of these theories, besides this last fantastic one can explain the variations and the asymmetry. Cause some people have silent heart attacks, with no pain. There should be major genetic differences between people to explain it and that's not the case. Then the asymmetry. It's always the left area of the chest or left hand. So that's when i started thinking, since i'm no stranger to temporary chest discomfort and even pain and had an episode of atrial fibrillation with rapid ventricular response (when i drove myself on the middle of the night (ambulance showed after i left) on black ice and a quarter inch of frost on the windshield to the hospital, with the pulse oximeter on the finger showing 200+ then on the freeway when there was no ice i went all the way to 90 mph because my truck has a speed limit sensor, for about 2 minutes that seemed an eternity 'till i reached the hospital.)

I believe it's the posture that triggers it. Your body through numerous chemical and hormonal changes during a heart attack, and i believe some of them are just trying to compensate the acute heart failure; through your brain or through some reflex mechanism, contracting certain muscles in the spine and creating a spine curvature, usually asymmetric (due to asymmetry of the position of the heart in the chest, there's more discussion in the paragraph below about this) that can put pressure on the nerves directly or through the extension of the asymmetrically pressured disks, creating the pain sensation.

(I read a few days ago about the importance of the position during sleeping. On the right side, it's better for the heart because there's less pressure and "more room" for the heart due to the position relative to other organs. Why heart needs more room to work? Because heart, like any muscle, can only contract but not expand. It expands only through relaxation when it regains its shape and only if there's no pressure on it allowing the blood to flow inside due to venous pressure. If you put pressure or lay other organs on it, it's not going to have room to expand. Things are aggravated by obesity, cause the intra and extra abdominal fat adds pressure to the abdominal cavity and inside the chest through diaphragm and hiatal hernias to the point that is making your stomach touch the bottom of your heart. Gas and abdominal bloating is another factor. One good sign that your heart does not have enough room to expand are palpitations triggered by your stomach touching the heart through hiatal hernias.)

Obesity And Fatty Liver Disease

My wife keeps on telling me how bad the liver of an obese person looks. Yellow. Doesn't have its color anymore.

Basically the officially recognized mechanism is: you eat and drink yourself to death, then your liver turns into fat before turning into scars when you get cirrhosis.

Let me tell you my opinion. This is not the causal chain. (I think studies are big wastes of money or maybe ways to funnel money and bribe the society while making it believing that this or that medicine or treatment or diet is good.)

I strongly believe that people overeat and do get obese because of the toxic environment ant inherent toxicity of processed food and chemistry based agriculture.

The body defends itself by craving more food when available because some of the toxins are being temporarily stored into fat, like first in the transformed liver cells then into the other fat tissues of the body and some other toxins are being absorbed by the extra fiber from "cleaner" foods.

If the "temporary" conditions become permanent, then you remain permanently obese, get fatty liver disease, and/or cirrhosis.

Human body is pretty well adapted to the use of alcohol. Of course it's a factor but not the main cause.

Overlapping Neural Networks

"One synapse, by itself, is more like a microprocessor--with both memory-storage and information-processing elements--than a mere on/off switch. In fact, one synapse may contain on the order of 1,000 molecular-scale switches. A single human brain has more switches than all the computers and routers and Internet connections on Earth" stanford november 2010 neuron imaging synapse processing" https://med.stanford.edu/news/all-news/2010/11/new-imaging-method-developed-at-stanford-reveals-stunning-details-of-brain-connections.html

There could be more than one type of molecular switch in a synapse, each type involving different neurotransmitters. This suggests that the synapse instead of acting as a microprocessor could simply change the path of the information from one neuron to another depending of what neurotransmitters prevail in that moment at the synapse.

Now we can think of the brain more like a dynamically re-configurable hardware with the possibility of multiple different (or even simultaneous) "neural pathways" between the same group of neurons. And if the neurotransmitters are not spread uniformly throughout a region, there goes the "classical neural network" model in favor of some ever changing and overlapping multiple neural networks.

It is obvious that until this discovery described in the article linked above was made, nobody could imagine this model.

However, let's hypothesize that a certain combination of neurotransmitters is distributed uniformly throughout the brain at a certain time. (Although it cannot last very long since these are very dynamic processes, as neurotransmitters are being secreted in different areas of the brain and also metabolized).

Nothing will happen, the brain would freeze in a certain state and thought pattern.

According to this there can be different "brain modes", depending of which type of molecular switches are favored or what mode the brain is in or how many of the overlapping networks are activated at a certain time, and if one is dominant.

It is possible that since memories being "written" when inside a certain area of the brain a certain combination of neurotransmitters is attained, to be retrieved by recreating the same combination of concentrations? Yes, but those conditions are being hard to achieve except by the brain itself, because i think there are gradients of the concentrations of different neurotransmitters that intersect each other creating that combination in very small areas.

Since some neurotransmitters are associated with emotions that means some combination of emotions at a certain time can lead to retrieving those memories?

Heart Muscle Regeneration

I have always been intrigued by the muscular breakdown process during exercise. When exercising beyond your capabilities the next day you have pain and your muscles ache. But it does not help with muscle growth. In fact athletes know this and try to avoid using different techniques. (Those who cheat know that using steroids actually helps with minimizing muscular damage so they can exercise more, stimulating muscle build-up.) Then if you go for a blood test you will have the CK enzyme elevated. So what exactly happens to your dead cells after muscular breakdown?

Then i said to myself. Your own dead cells contain DNA fragments (if DNA theory is true) that can be used in different areas of the body if needed, like in heart, better than from any other source. What if when exercising your body deliberately creates muscular breakdown in areas of your body and uses the cellular remains to rebuild your damaged heart or increase heart muscle?

If this is true, how many times this process can repeat itself until your heart is not fixable anymore?

Maybe even during CPR, where sometimes there is required energetic action from the part of the reviver, some breakdown occurs in the chest area where rhythmic pressure is applied.

Then thinking even further. Maybe heart muscle can be regenerated indefinetley. And it may be a quick process, a matter of hours or even dozens of minutes. Cause that'a how long a moderate muscular breakdown lasts.

How about the nerve circuits that synchronize heart? If you take a heart cell and put it in a Petri dish with nutrients it will continue to contract, rhythmically. All heart cells can do that including the new ones. The problem is how to synchronize them. And that can take a little longer until new nerve circuits build and train themselves. In this interval, fibrillation may occasionally occur. So now how do you fix that?

Defibrillator is one way this may be done. There are people with implanted defibrilators. I always wondered why they only work occasionally. Maybe just only when the heart is at the end of a decompensated regeneration cycle. When muscle buildup has been to great to be retrained by heart's own means.

But they might exist other more or less "natural" methods. I think of the entrained walking. When one person can walk in the same rhythm of the beating heart. Some nerve impulses from other parts of the body can overlap the heart electric currents and help with the retraining process. Other methods can be brain entraining through music or noise, breath entraining, etc. Even mantras, or poetry.

I was looking on the web for a memorable phrase the guy from Computer Age Auto Service once told me, citing the Bible. It was roughly the equivalent of "in the end times people will eat their own flesh" or something like that. But there is no such thing in the Bible. He might have said one of the verses from the Bible like from Ezekiel and i didn't get it right. I was pretty messed up that day as not sleeping for days and prepared for that conversation.

On another occasion one of the more senior programers at Quadramed told me something about one's body consuming itself when starving. He specified that we consume our own muscles for staying alive when fasting.

Yet on another occasion a therapist in a hospital told me that we can use our own body fat to convert it into sugar and keep going. However that is not true. Fat can only be used for keeping body temperature and for a few other "minor" things. To have your body and especially your brain functioning you need glucose or other sugars. I think protein can be broken down to either fat or sugar.

However in all tree instances above your body shuffles his own muscles or fat in order to survive.

Drugs vs Alcohol

For evolutionists only.

Drugs came much later in humans' lifes because they needed fire or refining to be used as they are used today. Even when fire was discovered they never abused drugs until modern days. Alcohol was used and abused from much older times and actually by other species too even before humans existed, in the form of rotten fruit. That's why humans have a gene that alows them to metabolize alcohol. Their brain or mind also is probably better adapted psychologically to the effects of it. With drugs, a totally different story. Europeans actually never came in contact with them until great explorations' times. That's why they have so much more devastating effects on humans' psychic.

Synchronization In The Human Cardiorespiratory System

Synchronization In The Human Cardiorespiratory System

Carsten Schafer,1,* Michael G. Rosenblum,1,† Hans-Henning Abel,2 and Jurgen Kurths1

Department of Physics, Potsdam University, Am Neuen Palais 10, Postfach 601553, D-14415 Potsdam, Germany

Department of Cardioanesthesiology, Stadtisches Klinikum Braunschweig, Braunschweig, Germany

Received 17 December 1998

We investigate synchronization between cardiovascular and respiratory systems in healthy humans under free-running conditions. For this aim we analyze nonstationary irregular bivariate data, namely, electrocardio-grams and measurements of respiratory flow. We briefly discuss a statistical approach to synchronization in noisy and chaotic systems and illustrate it with numerical examples; effects of phase and frequency locking are considered. Next, we present and discuss methods suitable for the detection of hidden synchronous epochs from such data. The analysis of the experimental records reveals synchronous regimes of different orders n:m and transitions between them; the physiological significance of this finding is discussed. S1063-651X 99 12407-3

PACS number s : 87.19.Hh, 87.17.Aa, 05.45. a

https://docs.google.com/open?id=0B-ShIhkErMIPSDJvOXVhU19EVkU

Arteries, Blood Volume

If with age or disease arteries narrow down to 50% in diameter as they say, that means 2/3 in space volume inside the artery that means that those people have up to 1/3 less blood than normal people, (veins do not narrow or dilate accordingly, half of the blood is stored in arteries). Never heard of anything like this, there must be something wrong with this theory.

Vitamin D, Cholesterol Mechanism

Since vitamin D is produced in your skin from cholesterol under sun exposure, is it possible your body allows more cholesterol in blood (and tissues like skin) as a response to vitamin D deficiency due to chronic lack of sun exposure?

Vitamin D deficiency high cholesterol

Inuit population need to intake much cholesterol in order to make vitamin D only in the skin of their face. Could this be the reason those from mongol race have big faces? Also fair skin allows the very little sunshine into your skin more easily.

Different DNA

"Most eukaryotic chromosomes include packaging proteins which, aided by chaperone proteins, bind to and condense the DNA molecule to prevent it from becoming an unmanageable tangle."

However there is a phase in cellular mitosis (division) when, before replication, chromosomes need to be unpackaged.

How do they manage to remain a "manageable tangle" during that period?

BTW there is another thing i don't understand in this video that shows a strand already unpackaged being processed by the enzymes helicase/polymerase to create two strands. Where it comes from the "material" added by the polymerase to create the second strand?

Can a packed chromosome perform the same function like transmitting information to ribosomes on how to build protein as an unpacked one? How fragment copies of DNA pass that "scaffolding" (image below)?

According to current theories, human chromosomes' "double stranded helicoidal DNA" range in length from 51 million to 245 million base pairs of atoms. At actual size, an average human cell chromosome totals up to 3 meters long and a few angstroms (10 to minus 10 meters) wide, made of two very long strings (strands) of atoms linked together as pairs. The longest known molecule.

To replicate, each double helix has to unwind and separate in two strands and and each strand of course has to stay in one piece. Each strand then acts as a template for a new strand or its new pair that needs to be packed back together. But at least at a certain moment when it is unpacked, it should be indeed an "unimaginable tangle".

And who or what is doing the job of unpacking/packing, scaffolding, etc..?

If you take a look at the picture below you'll see the 5 levels of winding or packaging of the DNA. At least at three different levels the DNA is packed with different types of "fiber".

http://www.bio.miami.edu/dana/pix/eukchromosome.jpg

Chromosomes are visible under microscope. Here is a video showing the very moment of the separation of the chromosomes during the mitosis (dividing) of one cell.

However no unpacking, unwinding/rewinding etc. of the double helix strands is apparent. They appear to separate like they were in the final stage from the picture above. According to the current theory the video basically shows each chromosome as a clew separating into two without any unwinding.

This video (animation) catches and earlier phase, "condensation" but still no replication. Condensation appears to be the last level of packaging as in the image above.

Why Chiropractic Works

For a better view, please click on the pictures then on the small icons below.

This idea came to me motivated by the dreadfull popping sound of my vertebrae during my first and only manipulation.

The chiropractor popped his fingers before the procedure right in front of me, "preparing me" for what was to come; the sound of maybe ten of my vertabrae popping like popcorn in the oven while he pressed once, shortly and decisively with both palms of his hands crossed on my spine! He explained me that the sound i will hear during the adjustment comes from the CO2 instantly boiling in the disk due to low pressure in a similar way the sinovial fluid would if you extended the articulation of you fingers and make them pop, due to the relative vacuum being created in the articulation (sinovial fluid). Obviously, he lost too many clients after the first visit that made it worthy to pop his fingers. As i was skeptic, he did it with several fingers until i started feeling for him.

I was never able to pop my fingers :( , but ever since i tried to figure how you can create vacuum in the disk by simply pressing perpendicularly on the axis of one's spine.

What's happening is the disks are being deformed as following: one side of the disk is being compressed and the other extended due to the fact that the angle between the axis of two adjacent vertebrae is changing. This can be observed in the pictures.The deformation is not equal on both sides. The compression on the side close to where the force is being applied during manipulation is smaller than the extension on the other side because the disk has a gel like structure inside but a hard "skin". During this procedure the disk is less compressed on one side than extended on the other. The result is a relative vacuum being created in the gel area that allows the eventual bulge to be sucked back in. It is literally a reduction or at least a partial reduction of the disk hernia.

The same with the succession of cat and dog yoga poses. The effect of this succession is very similar to the "adjustment" the chiropractors do.

This vacuum inside the disk is similar to what they obtain using traction machines, except is local and stronger. The traction machines extend all the spine and a few other articulations and then the extension effect is somewhat attenuated by a number of disks and articulations being extended in the same time.

Usually the explanation chiropractors themselves give about how it works is differrent, like alignement, subluxations and things like that. But if my explanation is the true one, it could lead to improvement of actual practices since it is obvious that the patient would benefit of rest after manipulation. If there is reduction of bulge that occurs the effect of reduction will be partially reversed by the compression created during standing and walking. With rest, the healing will be much faster and the number of manipulation decreased.

Although we cannot be sure of this either. Another phenomenon that occurs during manipulation is a hydraulic shock in all the adjacent tissues. The popping sound is there to prove it. This create a slight inflammation in all the surrounding tissues thus increasing the blood flow and accelerating the healing of the disk which is the biggest organ in the body that does not have its own blood supply and sucks its nutrients from the surrounding tissues. By walking and maintaining a higher heart rhythm and blood pressure, this effect is improved.